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Real-Time Imaging Systems

Remoscope
AI-powered cell morphology
and disease states.
Fast. Easy. Scalable.

Research Use Only Whole Blood Diagnostics CNS Liquid Biopsy
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Executive Summary

Remoscope · Investor Overview

Overview
  • Early-stage medtech emerging from Biohub
  • AI-powered label-free cell morphology platform
  • Leveraging years of internal development
CZ Biohub
Market Opportunity
1st · Research Use Only (RUO) assays
Cell viability, apoptosis & toxicity assays · small animal CSF models · CRO, Pharma, Academia
$0.8B
2nd · Whole Blood Diagnostics, critical care
Sepsis $1.2B · Sickle cell $1.1B · Malaria $0.8B
$3.1B
3rd · CNS cellular liquid biopsy
Cellular liquid biopsy for CNS disease
>$1B
Total TAM >$4.9B
Technical
  • Peer-reviewed clinical malaria validation
  • Sepsis: 90-99% AUC in minutes from whole blood
  • CNS cell counts validation performed
  • De-risked, field-hardened prototype design
  • Strong IP position: existing granted and new pending
Financing
  • Seed round · $6M ($5M venture + $1M non-dilutive) · 24-month runway
  • RUO launch + LMIC clinical studies
  • Phased development pipeline for regulatory
Patients waiting for care

Masafu General Hospital, Eastern Uganda · 30 April 2026

The Human Reality

A child presents with a dangerous fever.
The clinician assumes malaria and orders a test.

The technician is busy.
The family waits for hours.
They give up and go home.

The Diagnostic Gap

The world's most preventable deaths
happen without a diagnosis

3.6B
people lack access to essential diagnostics
Lancet Commission on Diagnostics, 2021
7M+
deaths per year from treatable infections
WHO Global Health Estimates, 2024
2 in 3
antibiotic prescriptions in LMICs made without lab confirmation
Lancet Infectious Diseases, 2019
Point of Care Today
  • Rapid tests — single disease, low sensitivity, antigen resistance
  • Manual blood smears — skill & labor intensive
  • Absence of correct test — resort to non-specific symptoms
Remoscope Remoscope
Centralized Lab
  • Hours to days turnaround
  • Cold chain & reagents required
  • Inaccessible in most LMICs
The Problem

Cellular fluid analysis requires
labor-intensive and skill-dependent workflows.

Across CRO, pharma, diagnostics, and clinical settings — the same bottleneck holds: sample prep, staining, manual microscopy, and specialist expertise.

Problem word cloud
Our Solution

Remoscope
An AI-powered
rapid diagnostic platform

Marker agnostic
Morphology-based
Immune to pathogen evolution
Expanding indications
New diseases via software update
No hardware change
No reagents · No cold chain
Label-free · works anywhere · Meets LMIC needs
Remoscope device
Platform Architecture

Your cells embedded, in real time.

Unprocessed blood
Flow cell
Disposable flow cell
with low COGS
Hardware
Remoscope
Label-free imaging
Up to 250M cells per day!
AI analysis
Platform Architecture

Same hardware. Many samples.

Remoscope instrument

Label-free · no reagents · edge compute

Sample type

Unprocessed whole blood

Adaptable software

One platform.
Many tasks.

> 3,000,000,000
cells imaged
Foundation model dataset generation
Disease-state feature discovery
Cell type and state classification
Instance segmentation and morphology
Published Clinical Validation

Malaria Diagnosis
Proven in the Field

Deployed in Eastern Uganda
P. falciparum · high sensitivity
Extending to other Plasmodium species
Ring stage parasites

Rings

Trophozoite stage

Trophozoites

Schizont stage

Schizonts

Tororo malaria field data

Clinical performance data · Tororo, Uganda

Field deployment in Uganda
Sepsis · Critical Care

Sepsis kills.
Speed is everything.

~7% mortality increase per hour of delayed treatment
"There is no gold standard"
Diagnosis is clinical · no rapid, objective bedside test
11 million deaths annually worldwide
UCSF EARLI Cohort
Sepsis clinical context

Am J Physiol Regul Integr Comp Physiol 324: R613–R624, 2023.

Sepsis · Point of Care

Sepsis Diagnosis · Whole Blood · Minutes

Sepsis classification: ROC curves, confusion matrix, and UMAP embeddings

Rule-out: 91.3% sensitivity · 97.0% specificity vs. all · UCSF EARLI cohort · sepsis.realtimeimagingsystems.com

Sepsis · remo-Map

Cell morphology fingerprints

Cell morphology map

Preliminary sickle cell map with small dataset

Sickle cell view
Study Goals
  • Record blood cell morphology maps for each participant
  • Apply a Kleihauer–Betke acid elution assay to lyse HbA cells
  • Run acid-eluted samples on Remoscope and quantify F-cell fraction
  • Quantify reticulocyte fractions and (stretch goal) HbF content per cell
  • Use the resulting data to train combined SCD + malaria remo-Map and remo-ID models
CNS Cellular Liquid Biopsy · Validation Data

Cellular Liquid Biopsy
for CNS Disease

Clinical ResultRemoscope Result
13 WBC/µL15 WBC/µL
0 WBC/µL0 WBC/µL
1 WBC/µL1 WBC/µL
7 WBC/µL7 WBC/µL
1 WBC/µL2.5 WBC/µL
5 WBC/µL4.5 WBC/µL
UCSF

In collaboration with Dr. Greer Waldrop
UCSF · Department of Neurology

CSF cells under Remoscope

White blood cells in a patient with neurological disease, imaged on Remoscope

Market Opportunity · 2 of 3

Whole Blood Diagnostics
Global Market · $3.1B TAM

Sepsis
$1.2B
US diagnostics market
  • 1.7M US cases/yr · 270K deaths
  • No rapid bedside objective test
  • Diagnosis based on subjective evaluation of non-specific symptoms
Validation in progress
Sickle Cell & Anemia
$1.1B
global screening & monitoring
  • 300M+ affected globally
  • Newborn screening · disease monitoring
  • High LMIC & US prevalence
Validation in progress
Malaria
$0.8B
global diagnostics market
  • 240M cases/yr · 90% sub-Saharan Africa
  • Rapid tests miss low-density infections
  • Antigen resistance emerging
Published · Uganda deployed
Why Remoscope
  • Same hardware · software-defined indications
  • Label-free · no reagents · no cold chain
  • Works at point of care, or centralized lab
Validation status
  • Malaria: peer-reviewed · Uganda deployment
  • Sepsis: High accuracy · UCSF EARLI cohort in progress
  • Sickle cell: morphology identification validated
Market Opportunity · 3 of 3

CNS Cellular Liquid Biopsy
>$1B TAM

The Opportunity

CSF cellular analysis is critical for diagnosing neurological disease — but requires lengthy lab processing today. No bedside tool can analyze CSF cells in real time.

Target Conditions
  • Meningitis & encephalitis · WBC differential
  • CNS lymphoma & leptomeningeal metastasis
  • Neuroimmunology · MS · autoimmune encephalitis
  • Post-surgical neurological monitoring
Our Validation

CSF WBC counts match clinical gold standard · label-free · no sample prep required

In collaboration with Dr. Greer Waldrop
UCSF · Department of Neurology

Why Remoscope
  • Same hardware as blood platform · no new capital
  • Real-time · bedside · no reagents or sample prep
  • Morphology-based cell classification
Software-Defined Platform

Add a sample type.
Ship a software update.

WB

Whole Blood

Malaria · Sepsis · CBC · Sickle Cell

P. falciparum

P. falciparum

Sepsis

Sepsis

Sickle cell

Sickle cell

CSF

CSF

WBC counting · gold standard match

CSF

Cerebrospinal fluid

UR

Urine

Cellular analysis · small animal studies

Coming soon

BAL

BAL & Other Fluids

Bronchoalveolar · peritoneal · differentials

Coming soon

24-Month Development Plan

Two parallel tracks to
revenue and regulatory readiness

Track 1 · Revenue

RUO Fast-Track Launch

Aim 1

Immediate RUO product launch · early revenue

Now

Product Definition

  • RUO-ready instrument specs finalized
  • Pricing strategy & go-to-market plan
Months 1–6

Commercial Launch

  • CRO & pharma partnerships
  • First instruments shipped
  • Flow cell scale-up: 4K → 20K/yr
Ongoing

Revenue & Diagnostic Expansion

  • Early revenue · de-risk platform claims
  • Expand assay library
Track 2 · Regulatory

Phased Development Pipeline

Aims 2 & 3

Manufacturable device · LMIC validation · WHO prequalification

Phase 0 · Now

Product Definition & DFM

  • ISO 13485 partner
  • Design controls & risk management
Planet Innovation
Phase 1 · Months 3–15

Alpha & Beta Systems

  • Performance optimization
  • Closed-loop AI model expansion
  • Neonatal sepsis · 5-part WBC diff
Phase 2.1 · Months 15–24

Prospective LMIC Studies

  • Tanzania & Uganda deployment
  • WHO prequalification filing
  • Distribution partnerships
Development Plan

Product Timeline

Product timeline
Seed Financing

Key Results to Achieve
with Seed Financing

1.
Product: RUO launch for CRO small animal CSF beachhead · manufacturing scale to 50K flow cells/year
2.
Phased PDP: Manufacturable Alpha instrument · ISO 13485 design controls complete
Planet Innovation
3.
Clinical: Prospective LMIC studies · Tanzania + Uganda · WHO prequalification pathway initiated
4.
AI expansion: Neonatal sepsis · Plasmodium species · 5-part WBC differential
5.
Regulatory: Launch US 510(k) process for critical care
The Advantage

Raising seed round after leveraging years of internal development at the Biohub.

Published clinical results · Field-hardened prototype · expanding indications · ISO 13485 started · Strong pharma and CRO interest

Use of Funds · $6M Seed
  • Engineering: Alpha system build-out & DFM
  • Clinical: LMIC prospective studies ($1M non-dilutive)
  • Business: RUO commercialization
  • 24 months runway to Series A in no-sales scenario
Financial Models

Interactive Revenue Models

Revenue streams
Instrument sales
Recurring flow cell revenue
Software licensing / model subscription

Overview chart shown at right. Select a scenario and plot type, then launch for full-screen detail.

The Team

10+ years building
this specific technology

Paul Lebel

Paul Lebel

Founder · CEO

PhD Applied Physics · Stanford · 751 citations · 7 patents

Ilakkiyan Jeyakumar

Ilakkiyan Jeyakumar

Founder · Control & Data Science

BASc Engineering Physics · UBC · edge compute · real-time systems

Nicholas Bratvold

Nicholas Bratvold

Founder · AI Lead

BASc Engineering Physics · UBC · remo-ID · remo-DB architect

Biohub Team Members

Rafael Gómez-Sjöberg · Michelle Khoo · Gregory Suematsu · Chris Charlton

Collaborators

UCSF · UC Berkeley · IDRC Uganda · CDC/KEMRI Kenya · Biohub · Pharma

Scientific Advisors

Prof. Joe DeRisi · Dr. Chaz Langelier · Dr. Teresa Kortz · Dr. Greer Waldrop · Prof. Grant Dorsey · Prof. Philip Rosenthal

Partnership & Investment

Ship it

Phase 1 · Now
RUO · Beachhead

Small Animal CRO Market

Hematotoxicity assays · small animal CSF models · early revenue, no regulatory clearance required

Pharma · cell assays · mechanism of action · $0.8B TAM

Phase 2 · Near Term
Whole Blood Diagnostics

Critical Care & Global Health

Sepsis · sickle cell · malaria

$3.1B global market

Phase 3 · Future
CNS Liquid Biopsy

Cellular CNS Diagnostics

Meningitis · CNS lymphoma · neuroimmunology

>$1B market

contact@realtimeimagingsystems.com  ·  sepsis.realtimeimagingsystems.com

Real-Time Imaging Systems · Redwood City, CA

Voice of Customer · RUO Market

10 In-Depth Interviews
Biopharma · CRO · Academia

7–8
avg. purchase intent (0–10 scale)
$80K–$300K
instrument price range
$10–$75
flow cell target
~90
est. samples / week per customer (range 20–500)
#1 · Biopharma ★ 7 / 10
Instrument
<$150K
Flow Cell
<$50
Software / yr
$2,500–$3,000
Key Applications
  • Immunophenotyping · WBC/RBC drug impact assays
  • T cell, B cell & lymphocyte marker analysis
  • Suspension & adherent cell characterization
  • Biomarker staining for cells in suspension
Market Opportunity · 1 of 3

Research Use Only (RUO) Assays
Early Revenue · $0.8B TAM

Label-free · no staining · no reagent prep · any lab member can run it

CRO

Contract Research

  • Hematotoxicity assays
  • Small-animal blood & CSF models
Rx

Pharma

  • Immune activation & mechanism of action
  • Two studies in planning with major pharma
Lab

Academic

  • Hematology & malaria research
  • Servicing pre-order list
Malaria · remo-ID

Attention on
infected red blood cells

High attention areas correlate with clinically-validated malaria detection model1 · extensible to other Plasmodium species

Malaria infected RBCs
Malaria ring-stage
Malaria high-confidence
Malaria P. falciparum

1 Trans. R. Soc. Trop. Med. Hyg. (2025) · doi:10.1093/trstmh/traf070

remo-ID · AI Classifier

Network Architecture

Swappable backbone (dinoV3/ResNet50/etc) · multiple instance learning · operates on raw cell images · no staining

remo-ID network architecture